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Article

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways.

The Journal of biological chemistry - 11 Jun 2004

Chen Chuan-Min, Gong Yusong, Zhang Min, Chen Jian-Jun

Abstract excerpt

Mutations in the leucine-rich repeat (LRR) domain of Nod2 have been implicated in the pathogenesis of Crohn's disease, yet the function of Nod2 and regulation of the Nod2 pathway remain unclear. In this study, we determined that mitogen-activated protein kinase kinase transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) interacts with Nod2 and is required for Nod2-mediated NF-kappaB activation. The...

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Identifiers

PMID: 15075345
DOI: 10.1074/jbc.M400682200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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