Article
Active and specific recruitment of a soluble cargo protein for endoplasmic reticulum exit in the absence of functional COPII component Sec24p.
Journal of cell science - 1 Apr 2004
Fatal Netta, Karhinen Leena, Jokitalo Eija, Makarow Marja
Abstract excerpt
Exit of proteins from the yeast endoplasmic reticulum (ER) is thought to occur in vesicles coated by four proteins, Sec13p, Sec31p, Sec23p and Sec24p, which assemble at ER exit sites to form the COPII coat. Sec13p may serve a structural function, whereas Sec24p has been suggested to operate in selection of cargo proteins into COPII vesicles. We showed recently that the soluble glycoprotein Hsp150 exited the ER in...
Topics
- Endoplasmic Reticulum
- Glycoproteins
- Heat-Shock Proteins
- Membrane Proteins
- Membrane Transport Proteins
- Microscopy, Electron
- Mutation
- Protein Structure, Tertiary
- Protein Transport
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Solubility
- Vesicular Transport Proteins