Article
[Identification of two different genetic mutation associated with silent phenotypes for human serum cholinesterase in Japanese].
Rinsho byori. The Japanese journal of clinical pathology - 1 May 1992
Hidaka K, Iuchi I, Yamasaki T, Ohhara M, Shoda T, Primo-Parmo S, Ladu B N
Abstract excerpt
Two different gene mutations associated with the silent phenotype for human serum cholinesterase were demonstrated. DNA from five individuals with silent gene phenotype of three unrelated Japanese families was amplified by the polymerase chain reaction (PCR) and analyzed by direct sequencing. The first instance demonstrated a G----C transversion at codon 365 from GGA (Gly) to CGA (Arg), which was seen in three...
Topics
- Asian People
- Base Sequence
- Cholinesterases
- Codon
- DNA
- Humans
- Japan
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction