HIV protease mutations associated with amprenavir resistance during salvage therapy: importance of I54M.

Abstract excerpt

OBJECTIVE: To examine the clinical significance of HIV protease mutations detected before and after therapy with amprenavir. STUDY DESIGN: Serial plasma HIV loads and protease gene mutations were monitored in 31 patients who received amprenavir, including 19 who had been exposed to other protease inhibitors (salvage therapy). Recombinant phenotyping was used to assess the significance of new mutations appearing...

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