Article
Impact of drug levels and baseline genotype and phenotype on the virologic response to amprenavir/ritonavir-based salvage regimens.
AIDS patient care and STDs - 1 Jan 2004
Valer Luisa, González de Requena Daniel, de Mendoza Carmen, Martin-Carbonero Luz, González-Lahoz Juan, Soriano Vincent
Abstract excerpt
Coadministration of amprenavir (APV) with small doses of ritonavir (RTV) results in a significant increase in APV plasma concentrations. Viruses showing resistance to other protease inhibitors (PI) may remain susceptible to APV, supporting a role for this drug in salvage therapy. We enrolled 35 patients who began a rescue intervention based on APV/RTV 600/100 mg twice daily. Their median viral load before...
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