Article
Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity.
Applied and environmental microbiology - 1 Apr 2004
Jansen Mickel L A, Daran-Lapujade Pascale, de Winde Johannes H, Piper Matthew D W, Pronk Jack T
Abstract excerpt
Prolonged cultivation (>25 generations) of Saccharomyces cerevisiae in aerobic, maltose-limited chemostat cultures led to profound physiological changes. Maltose hypersensitivity was observed when cells from prolonged cultivations were suddenly exposed to excess maltose. This substrate hypersensitivity was evident from massive cell lysis and loss of viability. During prolonged cultivation at a fixed specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
