Article
Interferons induce normal and aberrant retinoic-acid receptors type alpha in acute promyelocytic leukemia cells: potentiation of the induction of retinoid-dependent differentiation markers.
International journal of cancer - 27 Sept 1996
Gianní M, Zanotta S, Terao M, Rambaldi A, Garattini E
Abstract excerpt
Treatment of the acute promyelocytic (APL) cell line NB4 with interferon alpha (IFN(alpha)), as well as IFN(beta) and gamma, results in an increased expression of the transcripts coding for retinoic-acid receptor type alpha (RAR(alpha)) and the leukemia-specific retinoic acid receptor PML-RAR. Tr...
Topics
- Alkaline Phosphatase
- Cell Differentiation
- Cycloheximide
- Dactinomycin
- Drug Synergism
- Gene Expression
- Granulocyte Colony-Stimulating Factor
- HL-60 Cells
- Humans
- Interferon-alpha
- Interferon-beta
- Interferon-gamma
- Interferons
- Leukemia, Promyelocytic, Acute