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Article

Medical genetics: a marker for Stevens-Johnson syndrome.

Nature - 1 Apr 2004

Chung Wen-Hung, Hung Shuen-Iu, Hong Hong-Shang, Hsih Mo-Song, Yang Li-Cheng, Ho Hsin-Chun, Wu Jer-Yuarn, Chen Yuan-Tsong

Abstract excerpt

Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be...

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Identifiers

PMID: 15057820
DOI: 10.1038/428486a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Medical genetics: a marker for Stevens-Johnson syndrome.PMID 15057820Read ↗

Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations.Semantic proximity Read ↗

Genetic predisposition of life-threatening antiepileptic-induced skin reactions.Semantic proximity Read ↗

HLA-B Genotyping to Detect Carbamazepine-Induced Stevens-Johnson Syndrome: Implications for Personalizing MedicineSemantic proximity Read ↗

Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.Semantic proximity Read ↗

Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.Semantic proximity Read ↗

Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland.Semantic proximity Read ↗

Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.Semantic proximity Read ↗

Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.Semantic proximity Read ↗

Pharmacogenetics of toxic epidermal necrolysis.Semantic proximity Read ↗

Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study.Semantic proximity Read ↗

Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.Semantic proximity Read ↗

Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China.Semantic proximity Read ↗

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