Article
Angiotensin-converting enzyme insertion/deletion polymorphism modulates coronary release of tissue plasminogen activator in response to bradykinin.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2004
Ohira Naoto, Matsumoto Tetsuya, Tamaki Shinji, Takashima Hiroyuki, Tarutani Yasuhiro, Yamane Tetsunobu, Yasuda Yo, Horie Minoru
Abstract excerpt
The aim of this study was to assess the relationship between the angiotensin converting enzyme gene (ACE) genotype and endothelium-dependent coronary vasomotor and fibrinolytic activity. The ACE DD genotype has been reported to be a risk factor for myocardial infarction. However, the mechanism is unknown. The fibrinolytic and renin-angiotensin systems are linked via ACE at the vascular beds. We studied 73...
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