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Article

Macrophage interactions with neutrophils regulate Leishmania major infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2004

Ribeiro-Gomes Flávia L, Otero Ana C, Gomes Nitza A, Moniz-De-Souza Maria Carolina A, Cysne-Finkelstein Lea, Arnholdt Andrea C, Calich Vera L, Coutinho Sergio G, Lopes Marcela F, DosReis George A

Abstract excerpt

Macrophages are host cells for the pathogenic parasite Leishmania major. Neutrophils die and are ingested by macrophages in the tissues. We investigated the role of macrophage interactions with inflammatory neutrophils in control of L. major infection. Coculture of dead exudate neutrophils exacerbated parasite growth in infected macrophages from susceptible BALB, but killed intracellular L. major in resistant B6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15034061
DOI: 10.4049/jimmunol.172.7.4454

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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