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Article

Phenotypic and functional characteristics of HLA-DR+ neutrophils in Brazilians with cutaneous leishmaniasis.

Journal of leukocyte biology - 1 Mar 2017

Davis Richard E, Sharma Smriti, Conceição Jacilara, Carneiro Pedro, Novais Fernanda, Scott Phillip, Sundar Shyam, Bacellar Olivia, Carvalho Edgar M, Wilson Mary E

Abstract excerpt

The protozoan Leishmania braziliensis causes cutaneous leishmaniasis (CL) in endemic regions. In murine models, neutrophils (PMNs) are recruited to the site of infection soon after parasite inoculation. However, the roles of neutrophils during chronic infection and in human disease remain undefined. We hypothesized that neutrophils help maintain a systemic inflammatory state in subjects with CL. Lesion biopsies...

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Identifiers

PMID: 28076241
DOI: 10.1189/jlb.4A0915-442RR
PMCID: PMC5295851

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