Article
Classification and regression trees--studies of HIV reverse transcriptase inhibitors.
Journal of chemical information and computer sciences - 1 Jan 2000
Daszykowski M, Walczak B, Xu Q-S, Daeyaert F, de Jonge M R, Heeres J, Koymans L M H, Lewi P J, Vinkers H M, Janssen P A, Massart D L
Abstract excerpt
In this paper, the application of Classification And Regression Trees (CART) is presented for the analysis of biological activity of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). The data consist of the biological activities, expressed as pIC50, of 208 NNRTIs against wild-type HIV virus (HIV-1) and four mutant strains (181C, 103N, 100I, 188L) and the computed interaction energies with the Reverse...
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