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Article

A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway.

PLoS biology - 1 Mar 2004

Xu Haoxing, Jin Jie, DeFelice Louis J, Andrews Nancy C, Clapham David E

Abstract excerpt

Divalent metal transporter-1 (DMT1/DCT1/Nramp2) is the major Fe(2+) transporter mediating cellular iron uptake in mammals. Phenotypic analyses of animals with spontaneous mutations in DMT1 indicate that it functions at two distinct sites, transporting dietary iron across the apical membrane of intestinal absorptive cells, and transporting endosomal iron released from transferrin into the cytoplasm of erythroid...

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Identifiers

PMID: 15024413
DOI: 10.1371/journal.pbio.0020050
PMCID: PMC368157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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