Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions.

Genetics - 1 Feb 2004

Turelli Michael, Barton N H

Abstract excerpt

We investigate three alternative selection-based scenarios proposed to maintain polygenic variation: pleiotropic balancing selection, G x E interactions (with spatial or temporal variation in allelic effects), and sex-dependent allelic effects. Each analysis assumes an additive polygenic trait with n diallelic loci under stabilizing selection. We allow loci to have different effects and consider equilibria at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Data Interpretation, Statistical
Share to Genetic Variation
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multifactorial Inheritance

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15020487
DOI: 10.1534/genetics.166.2.1053
PMCID: PMC1470722

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions.PMID 15020487Read ↗

Stability of the G-matrix in a population experiencing pleiotropic mutation, stabilizing selection, and genetic drift.Semantic proximity Read ↗

Joint effects of pleiotropic selection and stabilizing selection on the maintenance of quantitative genetic variation at mutation-selection balance.Semantic proximity Read ↗

The effects of intraspecific competition and stabilizing selection on a polygenic trait.Semantic proximity Read ↗

Stability and response of polygenic traits to stabilizing selection and mutation.Semantic proximity Read ↗

Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.Semantic proximity Read ↗

Pleiotropic models of quantitative variation.Semantic proximity Read ↗

Pleiotropy and multilocus polymorphisms.Semantic proximity Read ↗

Genetic variation maintained in multilocus models of additive quantitative traits under stabilizing selection.Semantic proximity Read ↗

Epistasis in polygenic traits and the evolution of genetic architecture under stabilizing selection.Semantic proximity Read ↗

Additive genetic variance for fitness maintained by balancing selection.Semantic proximity Read ↗

Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance.Semantic proximity Read ↗

Mechanisms of adaptation in rapidly changing environments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.