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Article

Pleiotropy and multilocus polymorphisms.

Genetics - 1 Jan 1992

Gimelfarb A

Abstract excerpt

It is demonstrated that systems of two pleiotropically related characters controlled by additive diallelic loci can maintain under Gaussian stabilizing selection a stable polymorphism in more than two loci. It is also shown that such systems may have multiple stable polymorphic equilibria. Stabilizing selection generates negative linkage disequilibrium, as a result of which the equilibrium phenotypic variances...

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Identifiers

PMID: 1732163
DOI: 10.1093/genetics/130.1.223
PMCID: PMC1204796

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