Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pleiotropy and multilocus polymorphisms.

Genetics - 1 Jan 1992

Gimelfarb A

Abstract excerpt

It is demonstrated that systems of two pleiotropically related characters controlled by additive diallelic loci can maintain under Gaussian stabilizing selection a stable polymorphism in more than two loci. It is also shown that such systems may have multiple stable polymorphic equilibria. Stabilizing selection generates negative linkage disequilibrium, as a result of which the equilibrium phenotypic variances...

Topics

Genetic Linkage
Genetic Variation
Mathematics
Models, Genetic
Normal Distribution
Phenotype
Polymorphism, Genetic
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1732163
DOI: 10.1093/genetics/130.1.223
PMCID: PMC1204796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1732163-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropy and multilocus polymorphisms.PMID 1732163Read ↗

Pleiotropic models of quantitative variation.Semantic proximity Read ↗

Joint effects of pleiotropic selection and stabilizing selection on the maintenance of quantitative genetic variation at mutation-selection balance.Semantic proximity Read ↗

Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions.Semantic proximity Read ↗

The quantitative genetic consequences of pleiotropy under stabilizing and directional selection.Semantic proximity Read ↗

Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.Semantic proximity Read ↗

Genetic variation maintained in multilocus models of additive quantitative traits under stabilizing selection.Semantic proximity Read ↗

The balance between pleiotropic mutation and selection, when alleles have discrete effects.Semantic proximity Read ↗

Some additional results about polymorphisms in models of an additive quantitative trait under stabilizing selection.Semantic proximity Read ↗

Multivariate stabilizing selection and pleiotropy in the maintenance of quantitative genetic variation.Semantic proximity Read ↗

A pleiotropic model of phenotypic evolution.Semantic proximity Read ↗

Maintenance of multilocus variability under strong stabilizing selection.Semantic proximity Read ↗

Pleiotropic model of maintenance of quantitative genetic variation at mutation-selection balance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.