Article
Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP).
Virus research - 15 Mar 2004
Eichler Robert, Strecker Thomas, Kolesnikova Larissa, ter Meulen Jan, Weissenhorn Winfried, Becker Stephan, Klenk Hans Dieter, Garten Wolfgang, Lenz Oliver
Abstract excerpt
Lassa virus is the causative agent of a hemorrhagic fever endemic in west Africa. The RNA genome of Lassa virus encodes the glycoprotein precursor GP-C, a nucleoprotein (NP), the viral polymerase L and a small protein Z (11 kDa). Here, we analyze the role of Z protein for virus maturation. We have recently shown that expression of Z protein in the absence of other viral proteins is sufficient for the release of...
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