Article
Mutations conferring drug resistance affect eukaryotic expression of HIV type 1 reverse transcriptase.
AIDS research and human retroviruses - 1 Feb 2004
Isaguliants Maria G, Belikov Sergey V, Starodubova Elizaveta S, Gizatullin Rinat Z, Rollman Erik, Zuber Bartek, Zuber Anne Kjerrström, Grishchenko Olga I Andreeva, Rytting Ann-Sofie, Källander Clas F R, Kochetkov Sergey N, Karpov Vadim L, Wahren Britta
Abstract excerpt
Mutations in reverse transcriptase (RT) confer high levels of HIV resistance to drugs. However, while conferring drug resistance, they can lower viral replication capacity (fitness). The molecular mechanisms behind remain largely unknown. The aim of the study was to characterize the effect of drug-resistance mutations on HIV RT expression. Genes encoding AZT-resistant RTs with single or combined mutations D67N,...
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