Article
Genetic polymorphism at spinocerebellar ataxia 1 and 2 loci in Brazil.
Genetics and molecular research : GMR - 30 Dec 2003
Duarte Stenio F P, Gestinari Raquel S, Campos Junior Mário, Pimentel Márcia M G, Lima Marcelo A Costa
Abstract excerpt
Dynamic mutation involves the expansion of a tandem arrayed DNA sequence that is polymorphic in the population. This mechanism is associated with neurological/neuromuscular disorders and the pathology depends on the extension of the repeated tract, with a specific threshold for each disease. We made a PCR-based characterization of allelic polymorphism of SCA1 and SCA2 loci in a sample of 200 pairs of chromosomes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.