Article
Spinocerebellar ataxia type 10: common haplotype and disease progression rate in Peru and Brazil.
European journal of neurology - 1 Jul 2017
Gheno T C, Furtado G V, Saute J A M, Donis K C, Fontanari A M V, Emmel V E, Pedroso J L, Barsottini O, Godeiro-Junior C, van der Linden H, Ternes Pereira E, Cintra V P, Marques W, de Castilhos R M, Alonso I, Sequeiros J, Cornejo-Olivas M, Mazzetti P, Leotti V B, Jardim L B, Saraiva-Pereira M L
Abstract excerpt
BACKGROUND AND PURPOSE: Spinocerebellar ataxia type 10 is a neurodegenerative disorder that is due to an expanded ATTCT repeat tract in the ATXN10 gene. Our aim was to describe clinical characteristics and intragenic haplotypes of patients with spinocerebellar ataxia type 10 from Brazil and Peru. METHODS: Expanded alleles were detected by repeat-primed polymerase chain reaction. Disease progression was measured...
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