Article

Spinocerebellar ataxia type 2 has multiple ancestral origins

2023-09-12

Abstract excerpt

Spinocerebellar ataxia type 2 (SCA2) is an adult onset, dominant neurodegenerative disorder due to expansions of a CAG repeat tract at the ATXN2 gene. A few studies on ancestral haplotypes were performed so far, and the allele C at rs695871 was always found in SCA2 carriers. We aimed to describe SCA2 ancestral haplotypes constructed based on the SNPs rs9300319, rs3809274, rs695871, rs1236900 and rs593226, using th...

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Literature Corpus work: 8ea43419-684b-59a0-a812-a0d48600a206
DOI: 10.1101/2023.09.12.23295432

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