Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modification of smooth muscle cells to control phenotype and function in vascular tissue engineering.

Tissue engineering - 1 Jan 2000

Stegemann Jan P, Dey Nupur B, Lincoln Thomas M, Nerem Robert M

Abstract excerpt

Rat smooth muscle cells (SMCs) stably transfected with the gene for the phenotype regulating protein cyclic guanosine monophosphate-dependent protein kinase (PKG) were used as a cell source in the preparation of three-dimensional (3D) collagen type I vascular constructs. PKG-transfected cells expressed severalfold higher levels of the contractile protein smooth muscle alpha-actin (SMA), relative to untransfected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Biocompatible Materials
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to Time Factors

Share to Tissue Engineering

Share to Transfection

Source

Identifiers

PMID: 15009945
DOI: 10.1089/107632704322791844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modification of smooth muscle cells to control phenotype and function in vascular tissue engineering.PMID 15009945Read ↗

Phenotype modulation in vascular tissue engineering using biochemical and mechanical stimulation.Semantic proximity Read ↗

Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering.Semantic proximity Read ↗

Nitric oxide--cyclic GMP pathway regulates vascular smooth muscle cell phenotypic modulation: implications in vascular diseases.Semantic proximity Read ↗

Modulation of Smooth Muscle Cell Phenotype for Translation of Tissue-Engineered Vascular Grafts.Semantic proximity Read ↗

Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue-engineered small-diameter blood vessels.Semantic proximity Read ↗

Inhibition of cGMP-dependent protein kinase reverses phenotypic modulation of vascular smooth muscle cells.Semantic proximity Read ↗

Mechanical, biochemical, and extracellular matrix effects on vascular smooth muscle cell phenotype.Semantic proximity Read ↗

Activation of Transcription Factor GAX and Concomitant Downregulation of IL-1β and ERK1/2 Modulate Vascular Smooth Muscle Cell Phenotype in 3D Fibrous Scaffolds.Semantic proximity Read ↗

Directing phenotype of vascular smooth muscle cells using electrically stimulated conducting polymer.Semantic proximity Read ↗

Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism.Semantic proximity Read ↗

Phenotypic changes in cultured smooth muscle cells: limitation or opportunity for tissue engineering of hollow organs?Semantic proximity Read ↗

Phenotypic modulation of primary vascular smooth muscle cells by short-term culture on micropatterned substrate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.