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Article

Transthyretin is involved in depression-like behaviour and exploratory activity.

Journal of neurochemistry - 1 Mar 2004

Sousa João Carlos, Grandela Catarina, Fernández-Ruiz Javier, de Miguel Rosário, de Sousa Liliana, Magalhães Ana Isabel, Saraiva Maria João, Sousa Nuno, Palha Joana Almeida

Abstract excerpt

Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer beta-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the...

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Source

Identifiers

PMID: 15009661
DOI: 10.1046/j.1471-4159.2003.02309.x

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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