Article
HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han.
International journal of dermatology - 1 Mar 2004
Zhang Xuejun, Wei Shengcai, Yang Sen, Wang Zaixing, Zhang Anping, He Pingping, Wang Hongyan
Abstract excerpt
BACKGROUND: Psoriasis vulgaris is a chronic skin disorder characterized by infiltration of inflammatory elements, keratinocyte hyperproliferation and altered differentiation. Although the pathogenesis of psoriasis is not fully understood, there is solid evidence of a susceptibility locus in the human leukocyte antigen (HLA) region. OBJECTIVES: To investigate whether HLA-DQA1 and DQB1 alleles are associated with...
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