NF‐κB‐ and c‐Jun‐dependent regulation of human cytomegalovirus immediate‐early gene enhancer/promoter in response to lipopolysaccharide and bacterial CpG‐oligodeoxynucleotides in macrophage cell line RAW 264.7

Abstract excerpt

The cytomegalovirus immediate-early (CMV IE) gene enhancer/promoter regulates the expression of immediate-early gene products and initiation of CMV replication. TNF-alpha and lipopolysaccharide (LPS) strongly activate the promoter, possibly involving NF-kappaB. CpG-oligodeoxynucleotides (CpG-ODNs), which contain unmethylated CpG dinucleotides in the context of particular base sequences, have gained attention...

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