Possible multiple origins of replication in primate mitochondria: Alternative role of tRNA sequences.

doi:10.1016/j.jtbi.2005.11.035

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Article

Possible multiple origins of replication in primate mitochondria: Alternative role of tRNA sequences.

Journal of theoretical biology - 21 Jul 2006

Seligmann Hervé, Krishnan Neeraja M, Rao Basuthkar J

Abstract excerpt

DNA replication in vertebrate mitochondria is usually directional, leaving different portions of the genome single-stranded for different periods of time. During this time, mutations resulting from deaminations of cytosines to thymines and adenines to guanines accumulate on the heavy strand. Therefore, T/C and G/A ratios increase along mitochondrial genomes, proportionally to the time spent single-stranded during...

Topics

Animals
Computational Biology
DNA Replication
DNA, Mitochondrial
Evolution, Molecular
Mitochondria
Models, Genetic
Multigene Family
Mutation
Primates
RNA, Transfer
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 16430924
DOI: 10.1016/j.jtbi.2005.11.035

Provenance

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