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Article

Engineering Lactococcus lactis for production of mannitol: high yields from food-grade strains deficient in lactate dehydrogenase and the mannitol transport system.

Applied and environmental microbiology - 1 Mar 2004

Gaspar Paula, Neves Ana Rute, Ramos Ana, Gasson Michael J, Shearman Claire A, Santos Helena

Abstract excerpt

Mannitol is a sugar polyol claimed to have health-promoting properties. A mannitol-producing strain of Lactococcus lactis was obtained by disruption of two genes of the phosphoenolpyruvate (PEP)-mannitol phosphotransferase system (PTS(Mtl)). Genes mtlA and mtlF were independently deleted by double-crossover recombination in strain L. lactis FI9630 (a food-grade lactate dehydrogenase-deficient strain derived from...

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Identifiers

PMID: 15006767
DOI: 10.1128/AEM.70.3.1466-1474.2004
PMCID: PMC368346

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PTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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