Article
Comparison of the efficacy, safety and predictive value of HIV genotyping using distinct ritonavir-boosted protease inhibitors.
International journal of antimicrobial agents - 1 Dec 2002
Barreiro Pablo, Camino Nuria, de Mendoza Carmen, Valer Luisa, Núñez Marina, Martín-Carbonero Luz, González-Lahoz Juan, Soriano Vincent
Abstract excerpt
The pharmacokinetic profile of protease inhibitors (PI) is improved significantly by adding low doses of ritonavir (rit). The use of rit-boosted PI allows the reduction of pill burden, improves dosing schedules and enhances drug exposure, all factors that have been associated with a greater benefit of antiretroviral therapy. All patients receiving rit 100 mg bid together with saquinavir (SQV) soft gel 1000 mg...
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