Article
Association of polymorphisms in Th1, Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2004
Nieters A, Linseisen J, Becker N
Abstract excerpt
BACKGROUND: Hayfever is determined by an interaction of environmental and genetic factors and biologically characterized by an imbalanced T helper cell 1 (Th1) and Th2 immune response and elevated IgE levels against inhalant allergens. Indications exist that polymorphisms in cytokine genes involved in the regulation of the Th1/Th2 balance may contribute to the allergic phenotype. OBJECTIVE: We investigate whether...
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