Article
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains.
Acta neuropathologica - 1 Nov 2007
Ingelsson Martin, Ramasamy Karunya, Russ Carsten, Freeman Stefanie H, Orne Jennifer, Raju Susan, Matsui Toshifumi, Growdon John H, Frosch Matthew P, Ghetti Bernardino, Brown Robert H, Irizarry Michael C, Hyman Bradley T
Abstract excerpt
Some cases of familial frontotemporal dementia (FTD) leading to frontotemporal lobar degeneration (FTLD) are caused by mutations in tau on chromosome 17 (FTDP-17). Certain mutations alter the ratio between four (4R tau) and three (3R tau) repeat tau isoforms whereas cases with progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) mainly have 4R tau brain pathology. We assessed tau mRNA and...
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