Article
Quantitative trait Loci specifying the response of body temperature to dietary restriction.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Feb 2004
Rikke Brad A, Yerg John E, Battaglia Matthew E, Nagy Tim R, Allison David B, Johnson Thomas E
Abstract excerpt
Dietary restriction (DR) retards aging and mortality across a variety of taxa. In homeotherms, one of the hallmarks of DR is lower mean body temperature (T(b)), which might be directly responsible for some aspects of DR-mediated life extension. We conducted a quantitative trait locus (QTL) analysis of the response of T(b) to DR in mice using a panel of 22 LSXSS recombinant inbred strains, tested in two cohorts....
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