Article
Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes.
Diabetes - 1 Mar 2004
Ray David, Mishra Manoj, Ralph Shirley, Read Ian, Davies Robert, Brenchley Paul
Abstract excerpt
Diabetic retinopathy and nephropathy cause significant morbidity in patients with diabetes. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications. We previously reported transfection studies showing the VEGF -460 and VEGF +405 polymorphisms to increase basal VEGF promoter activity by 71% compared with the...
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