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Article

What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?

PloS one - 1 Jan 2013

Bonnefond Amélie, Saulnier Pierre-Jean, Stathopoulou Maria G, Grarup Niels, Ndiaye Ndeye Coumba, Roussel Ronan, Nezhad Mohsen Azimi, Dechaume Aurélie, Lantieri Olivier, Hercberg Serge, Lauritzen Torsten, Balkau Beverley, El-Sayed Moustafa Julia S, Hansen Torben, Pedersen Oluf, Froguel Philippe, Charpentier Guillaume, Marre Michel, Hadjadj Samy, Visvikis-Siest Sophie

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a key chemokine involved in tissue growth and organ repair processes, particularly angiogenesis. Elevated circulating VEGF levels are believed to play a role in type 2 diabetes (T2D) microvascular complications, especially diabetic retinopathy. Recently, a genome-wide association study identified two common single nucleotide polymorphisms (SNPs; rs6921438 and...

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Diabetes Complications
Diabetes Mellitus, Type 2
Diabetic Nephropathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Diabetic Retinopathy

Genome-Wide Association Study

Glycated Hemoglobin

Longitudinal Studies

Vascular Endothelial Growth Factor A

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Identifiers

PMID: 23405237
DOI: 10.1371/journal.pone.0055921
PMCID: PMC3566098

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