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Article

DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.

Biochemistry - 10 Apr 2007

Ioanoviciu Alexandra, Yukl Erik T, Moënne-Loccoz Pierre, de Montellano Paul R Ortiz

Abstract excerpt

Mycobacterium tuberculosis can exist in the actively growing state of the overt disease or in a latent quiescent state that can be induced, among other things, by anaerobiosis. Eradication of the latent state is particularly difficult with the available drugs and requires prolonged treatment. DevS is a member of the DevS-DevR two-component regulatory system that is thought to mediate the cellular response to...

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Identifiers

PMID: 17371046
DOI: 10.1021/bi602422p
PMCID: PMC2518089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.PMID 17371046Read ↗

DevR–DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevRSemantic proximity Read ↗

DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis.Semantic proximity Read ↗

A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.Semantic proximity Read ↗

Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes.Semantic proximity Read ↗

Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis.Semantic proximity Read ↗

Different roles of DosS and DosT in the hypoxic adaptation of Mycobacteria.Semantic proximity Read ↗

Phosphatase-defective DevS sensor kinase mutants permit constitutive expression of DevR-regulated dormancy genes in Mycobacterium tuberculosis.Semantic proximity Read ↗

A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis.Semantic proximity Read ↗

Molecular analysis of the dormancy response inMycobacterium smegmatis: expression analysis of genes encoding the DevR–DevS two-component system, Rv3134c and chaperone α-crystallin homologuesSemantic proximity Read ↗

Essentiality of DevR/DosR Interaction with SigA for the Dormancy Survival Program in Mycobacterium tuberculosisSemantic proximity Read ↗

Appropriate DevR (DosR)-mediated signaling determines transcriptional response, hypoxic viability and virulence of Mycobacterium tuberculosis.Semantic proximity Read ↗

Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis.Semantic proximity Read ↗

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