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Article

Phosphatase-defective DevS sensor kinase mutants permit constitutive expression of DevR-regulated dormancy genes in Mycobacterium tuberculosis.

The Biochemical journal - 15 May 2020

Kumari Priyanka, Kumar Sudhir, Kaur Kohinoor, Gupta Umesh Datta, Bhagyawant Sameer Suresh, Tyagi Jaya Sivaswami

Abstract excerpt

The DevR-DevS/DosR-DosS two-component system of Mycobacterium tuberculosis, that comprises of DevS sensor kinase and DevR response regulator, is essential for bacterial adaptation to hypoxia by inducing dormancy regulon expression. The dominant phosphatase activity of DevS under aerobic conditions enables tight negative control, whereas its kinase function activates DevR under hypoxia to induce the dormancy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32309848
DOI: 10.1042/BCJ20200113

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Phosphatase-defective DevS sensor kinase mutants permit constitutive expression of DevR-regulated dormancy genes in Mycobacterium tuberculosis.PMID 32309848Read ↗

DevS/DosS sensor is bifunctional and its phosphatase activity precludes aerobic DevR/DosR regulon expression in Mycobacterium tuberculosis.Semantic proximity Read ↗

DevR–DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevRSemantic proximity Read ↗

Essentiality of DevR/DosR Interaction with SigA for the Dormancy Survival Program in Mycobacterium tuberculosisSemantic proximity Read ↗

Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes.Semantic proximity Read ↗

Appropriate DevR (DosR)-mediated signaling determines transcriptional response, hypoxic viability and virulence of Mycobacterium tuberculosis.Semantic proximity Read ↗

The α10 helix of DevR, the Mycobacterium tuberculosis dormancy response regulator, regulates its DNA binding and activity.Semantic proximity Read ↗

DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.Semantic proximity Read ↗

Molecular analysis of the dormancy response inMycobacterium smegmatis: expression analysis of genes encoding the DevR–DevS two-component system, Rv3134c and chaperone α-crystallin homologuesSemantic proximity Read ↗

Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosis.Semantic proximity Read ↗

A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.Semantic proximity Read ↗

Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates <i>Mycobacterium tuberculosis</i> sensitivity to nitric oxide stressSemantic proximity Read ↗

Identification of gene targets against dormant phase Mycobacterium tuberculosis infectionsSemantic proximity Read ↗

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