Article
Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan.
Muscle & nerve - 1 Mar 2004
Shi Weixing, Chen Zaili, Schottenfeld Jodi, Stahl Richard C, Kunkel Louis M, Chan Yiu-Mo
Abstract excerpt
Mutations in sarcoglycans (SG) have been reported to cause autosomal-recessive limb-girdle muscular dystrophy (LGMD) and dilated cardiomyopathy. In skeletal and cardiac muscle, sarcoglycans exist as a complex of four transmembrane proteins (alpha-, beta-, gamma-, and delta-SG). In this study, the assembly of the sarcoglycan complex was examined in a heterologous expression system. Our results demonstrated that...
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