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Article

ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1.

The Journal of biological chemistry - 7 May 2004

Deval Emmanuel, Salinas Miguel, Baron Anne, Lingueglia Eric, Lazdunski Michel

Abstract excerpt

ASIC3, an acid-sensing ion channel subunit expressed essentially in sensory neurons, has been proposed to be involved in pain. We show here for the first time that native ASIC3-like currents were increased in cultured dorsal root ganglion (DRG) neurons following protein kinase C (PKC) stimulation...

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Source

Identifiers

PMID: 14976185
DOI: 10.1074/jbc.M313078200

Genes

ASIC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14976185-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1.PMID 14976185Read ↗

The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons.Semantic proximity Read ↗

Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).Semantic proximity Read ↗

C-Jun N-terminal kinase post-translational regulation of pain-related Acid-Sensing Ion Channels 1b and 3Semantic proximity Read ↗

Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts.Semantic proximity Read ↗

Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromersSemantic proximity Read ↗

A sensory neuron-specific, proton-gated ion channel.Semantic proximity Read ↗

Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry.Semantic proximity Read ↗

Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.Semantic proximity Read ↗

The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function.Semantic proximity Read ↗

Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones.Semantic proximity Read ↗

Genetic exploration of the role of acid-sensing ion channels.Semantic proximity Read ↗

Two di-leucine motifs regulate trafficking and function of mouse ASIC2a.Semantic proximity Read ↗

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