Article
Power of maximum HLOD tests to detect linkage to obesity genes.
BMC genetics - 31 Dec 2003
Yoo Yun Joo, Huo Yanling, Ning Yuming, Gordon Derek, Finch Stephen, Mendell Nancy R
Abstract excerpt
BACKGROUND: We investigate the power of heterogeneity LOD test to detect linkage when a trait is determined by several major genes using Genetic Analysis Workshop 13 simulated data. We consider three traits, two of which are disease-causing traits: 1) the rate of change in body mass index (BMI); and 2) the maximum BMI; and 3) the disease itself (hypertension). Of interest is the power of "HLOD2", the maximum...
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