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Article

[From gene to disease; spastin and hereditary spastic paraparesis].

Nederlands tijdschrift voor geneeskunde - 24 Jan 2004

Bruyn R P, Frants R R

Abstract excerpt

Hereditary spastic paraparesis (HSP) belongs to a group of genetically and clinically heterogeneous disorders characterised by progressive spasticity of the legs and hyperreflexia. A further clinical distinction is drawn between pure and complicated HSP depending on the presence of other neurological and non-neurological signs. HSP may be inherited either as autosomal dominant, recessive, or X-linked. Twenty-two...

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Source

Identifiers

PMID: 14974310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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