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Article

Clinical and pathologic findings in hereditary spastic paraparesis with spastin mutation.

Neurology - 12 Jul 2000

White K D, Ince P G, Lusher M, Lindsey J, Cookson M, Bashir R, Shaw P J, Bushby K M

Abstract excerpt

OBJECTIVE: To describe a family with chromosome 2p-linked hereditary spastic paraparesis (HSP) associated with dementia and illustrate the cerebral pathology associated with this disorder. BACKGROUND: HSP comprises a heterogeneous group of inherited disorders in which the main clinical feature is severe, progressive lower limb spasticity. Nongenetic classification relies on characteristics such as mode of...

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PMID: 10891911
DOI: 10.1212/wnl.55.1.89

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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