Article
Metabolic susceptibility genes and prostate cancer risk in a southern European population: the role of glutathione S-transferases GSTM1, GSTM3, and GSTT1 genetic polymorphisms.
The Prostate - 1 Mar 2004
Medeiros Rui, Vasconcelos André, Costa Sandra, Pinto Daniela, Ferreira Paula, Lobo Francisco, Morais António, Oliveira Jorge, Lopes Carlos
Abstract excerpt
BACKGROUND: Glutathione S-transferase (GST) metabolic enzymes may be involved in the development of human cancer. Genetic polymorphisms have been reported in GSTM1, GSTM3, and GSTT1 with functional alterations and influencing cancer risk. METHODS: We analyzed DNA samples from 335 (670 alleles) unrelated individuals, 185 community control subjects, and 150 prostate cancer (PC) patients, for GSTM1, GSTM3, and GSTT1...
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