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Article

eIF4E isoform 2 in Schizosaccharomyces pombe is a novel stress-response factor.

EMBO reports - 1 Mar 2004

Ptushkina Marina, Malys Naglis, McCarthy John E G

Abstract excerpt

Cap-binding proteins of the elF4E family are generally involved in mediating ribosome recruitment to capped mRNA via an interaction with the initiation factor elF4G. However, Schizosaccharomyces pombe has two elF4E isoforms, one of which (elF4E2, encoded by tif452) has a relatively low affinity for elF4G. We show that tif452 is required for specific stress responses. An S. pombe, tif452delta mutant manifests slow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14968130
DOI: 10.1038/sj.embor.7400088
PMCID: PMC1299000

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