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Article

Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase.

Biochemistry - 24 Feb 2004

Olteanu Horatiu, Wolthers Kirsten R, Munro Andrew W, Scrutton Nigel S, Banerjee Ruma

Abstract excerpt

Human methionine synthase reductase (MSR) is a protein containing both FAD and FMN, and it reactivates methionine synthase that has lost activity due to oxidation of cob(I)alamin to cob(II)alamin. In this study, anaerobic redox titrations were employed to determine the midpoint reduction potentials for the flavin cofactors in two highly prevalent polymorphic variants of MSR, I22/L175 and M22/S175. The latter is a...

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PMID: 14967039
DOI: 10.1021/bi035910i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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