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Article

Engineered mesenchymal cell-based patches as controlled VEGF delivery systems to induce extrinsic angiogenesis.

Acta biomaterialia - 15 Sept 2016

Boccardo Stefano, Gaudiello Emanuele, Melly Ludovic, Cerino Giulia, Ricci Davide, Martin Ivan, Eckstein Friedrich, Banfi Andrea, Marsano Anna

Abstract excerpt

UNLABELLED: Therapeutic over-expression of Vascular Endothelial Growth Factor (VEGF) by transduced progenitors is a promising strategy to efficiently induce angiogenesis in ischemic tissues (e.g. limb muscle and myocardium), but tight control over the micro-environmental distribution of the dose is required to avoid induction of angioma-like tumors. Therapeutic VEGF release was achieved by purified transduced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27469308
DOI: 10.1016/j.actbio.2016.07.041

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