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A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

16 Feb 2012

Abstract excerpt

Increases in cellular Reactive Oxygen Species (ROS) concentration with age have been observed repeatedly in mammalian tissues. Concomitant increases in the proportion of replicatively senescent cells in ageing mammalian tissues have also been observed. Populations of mitotic human fibroblasts cultured in vitro, undergoing transition from proliferation competence to replicative senescence are useful models of...

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Share to Epigenetics and DNA Methylation
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PMID: 22359661
DOI: 10.1371/journal.pone.0032117

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