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Article

Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma.

American journal of respiratory and critical care medicine - 1 May 2004

Birkisson Illugi F, Halapi Eva, Bjornsdottir Unnur S, Shkolny Dana L, Adalsteinsdottir Elva, Arnason Thor, Gislason David, Gislason Thorarinn, Gulcher Jeffrey, Stefansson Kari, Hakonarson Hakon

Abstract excerpt

Recent evidence suggests that deficiency in the Th1 cytokine pathway may underlie the susceptibility to allergic asthma. This study examined whether (1) single-nucleotide polymorphisms exist in the promoter region of the two interleukin (IL)-12 subunit genes in patients with asthma; (2) messenger RNA and protein expressions of signal transducers and activators of transcription, IL-12, IFN-gamma, and their...

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Share to Asthma
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypersensitivity, Immediate

Share to Interferon-gamma

Share to Interleukin-12

Share to Th1 Cells

Source

Identifiers

PMID: 14962816
DOI: 10.1164/rccm.200302-228OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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