Article
Single-nucleotide polymorphisms of vascular endothelial growth factor in psoriasis of early onset.
The Journal of investigative dermatology - 1 Jan 2004
Young Helen S, Summers Angela M, Bhushan Monica, Brenchley Paul E C, Griffiths Christopher E M
Abstract excerpt
Vascular endothelial growth factor (VEGF)--a stimulus of angiogenesis--is produced by epidermal keratinocytes, and elevated levels have been found in plaques of psoriasis. Polymorphisms in the VEGF gene regulate production of VEGF. We postulated that patients with psoriasis may have altered systemic expression of VEGF consequent upon programming at the genomic level. We investigated the genetic basis of VEGF...
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