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Article

Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis.

The Journal of investigative dermatology - 1 Feb 2006

Young Helen S, Summers Angela M, Read Ian R, Fairhurst David A, Plant Darren J, Campalani Emanuela, Smith Catherine H, Barker Jonathan N W N, Detmar Michael J, Brenchley Paul E C, Griffiths Christopher E M

Abstract excerpt

Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and -460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+419) through which retinoids, an established systemic therapy for psoriasis, can block production of VEGF. We report that peripheral blood mononuclear cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16385345
DOI: 10.1038/sj.jid.5700096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis.PMID 16385345Read ↗

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