Autoantibodies to lipocortin-1 are associated with impaired glucocorticoid responsiveness in rheumatoid arthritis.

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Article

Autoantibodies to lipocortin-1 are associated with impaired glucocorticoid responsiveness in rheumatoid arthritis.

The Journal of rheumatology - 1 Nov 1992

Podgorski M R, Goulding N J, Hall N D, Flower R J, Maddison P J

Abstract excerpt

Autoantibodies to the antiinflammatory protein lipocortin-1 have been found in patients with rheumatoid arthritis (RA) receiving oral glucocorticoids. The highest antibody titers correlated with a requirement for high maintenance doses of steroid (> 7.5 mg/day prednisolone). Forty-two patients wi...

Topics

Aged
Annexin A1
Arthritis, Rheumatoid
Autoantibodies
Female
Glucocorticoids
Humans
Hydrocortisone
Immunoglobulin G
Immunoglobulin M
Injections, Intravenous
Leukocytes
Male
Methylprednisolone
Middle Aged
Phenotype

Source

Open in PubMed

Identifiers

PMID: 1491384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1491384-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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