Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic destabilization of Candida albicans by hydroxyurea.

Microbios - 1 Jan 1991

Sarachek A, Henderson L A, Eddy K B

Abstract excerpt

Candida albicans is a commensal component of the normal human microflora, but frequently causes infections in persons undergoing treatment for malignancies. The cytotoxicity and genotoxicity of the antineoplastic agent hydroxyurea (HU) for the yeast is demonstrated. Cultivation of the organism on defined complete medium in the presence of HU induced growth inhibition or cell death, gene mutations, segregations of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Hydroxyurea
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Recombination, Genetic

Source

Identifiers

PMID: 2014007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Genetic destabilization of Candida albicans by hydroxyurea.PMID 2014007Read ↗

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicansSemantic proximity Read ↗

Genomic variation in C. albicans.Semantic proximity Read ↗

Evaluation of the genotoxic spectrum of cisplatin for Candida albicans.Semantic proximity Read ↗

Genomic plasticity of the human fungal pathogen Candida albicans.Semantic proximity Read ↗

Heme deficiency sensitizes yeast cells to oxidative stress induced by hydroxyurea.Semantic proximity Read ↗

Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicansSemantic proximity Read ↗

The Candida albicans Ku70 modulates telomere length and structure by regulating both telomerase and recombination.Semantic proximity Read ↗

Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicans.Semantic proximity Read ↗

Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stressSemantic proximity Read ↗

Multiple chromosomal and phenotypic changes in spontaneous mutants of Candida albicans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.