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Article

Biological complexity and strategies for finding DNA variations responsible for inter-individual variation in risk of a common chronic disease, coronary artery disease.

Annals of medicine - 1 Dec 1992

Sing C F, Haviland M B, Templeton A R, Zerba K E, Reilly S L

Abstract excerpt

Most common chronic diseases of humans aggregate, but do not segregate, in families. The segregation-linkage research paradigm has not provided great insights into their genetic etiology. In this paper, using coronary artery disease as an example, we discuss hierarchical organization, coherence, emergent properties and dynamism as features that characterize the complexity of genotype-phenotype relationships. We...

Topics

Coronary Disease
DNA
Disease Susceptibility
Environment
Genetic Markers
Genetic Variation
Humans
Models, Genetic
Mutation
Research Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1485951
DOI: 10.3109/07853899209167008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1485951-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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